AMES MPF 98/100, Ames II Test - Miniaturized Assay ICH M7
AMES MPF 98/100, Ames II Test - Miniaturized Assay ICH M7

Art. No.:

Service Analytics for 1 - X Compounds
Miniaturized Ames MPF Test or Ames II Test for early Screening purposes and for the detection of genotoxic impurities. The Assay comes in a liquid and 384-well microplate format for testing with only few mg of test article assessed on 2 Ames strains TA98 and TA100 or TA98 and TAMix. The Ames Microplate Format test uses liquid media and 384well microplates with a readout based on a colourchange. It has been used for over 10 years at several major pharmaceutical companies to screen for genotoxic potential of genotoxic impurities. The Assay is run with two tester strains, in compliance with ICH M7 Guideline. Correlation between the Ames MPF, Ames II Systems and the agar plate Ames preincubation method is excellent shown in a significant number of publications.


  • High sensitivity and excellent correlation with agar plate test
  • 4 times less test compound as compared to the agar plate test
  • Less hands-on-time and simultaneous processing of several replicates
  • Automation with pipetting robots, e.g. EpiMotion (Eppendorf), Januz (Beckman)
  • 3Rs - 12 fold less consumption of rat liver liver S9, less test animals
  • Less error prone due to easy colorimetric read-out
  • Waste - Significant less plastic waste and thus reduced contaminated waste in environment

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    Service Analytics Leaflet

    Service Analytics for Genotoxicity Leaflet