The Ames Microplate Format - Ames MPF test uses liquid media and 384well microplates with a readout based on a colourchange. It has been used for over 15 years at several major pharmaceutical companies for screening the genotoxic potential of early drug candidates maximising hazard identification with minimizing resource expenditure. The Assay is run with two or five tester strains, in compliance with OECD Guideline 471 and can be automated with pipetting robots, e.g. EpiMotion (Eppendorf), Januz (Beckman). Correlation between the Ames MPF System and the agar plate Ames preincubation method is excellent as the significant number of publications show.
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