XenoSkin P BM - Dermatomed Porcine Buccal Mucosa Discs - Serves also as Vaginal Model

XenoSkin P BM - Dermatomed Porcine Buccal Mucosa Discs - Serves also as Vaginal Model

Art. No.: PBM-D20D-8

Disc 8 mm diameter, minimal order quantity 10 pieces

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Product Description
Documents (2)

XenoSkin P BM is an ex vivo Porcine dermatomed Buccal Mucosa disc for in vitro mucosa permeation tests, absorption or penetration safety studies of chemicals, agrochemicals, pharmaceuticals, cosmetics or biocides and pesticides. The mucosa explants are also used as in vitro method for the evaluation of the barrier properties of medical devices for cutaneous use according Regulation 2017/745, Rule 21. The discs can be used for the safety assessment according to OECD 428, EFSA, EMA, FDA guidelines. XenoSkin P BM mucosa models are also used in place of colon mucosa or vaginal mucosa models and are replacing test animals.

XenoSkin H discs and porcine mucosas are excellent in vitro models for selecting drug candidates for dermal application, characterization of topical dosage forms, quality and safety assessment, selecting a suitable transdermal vehicle. XenoSkin H explants are replacing test animals.

Characteristics for in vitro dermal Permeation Testing

abdominal or face ex vivo skin

average age donor 45 years

aproved for absence of HBV, HCV, HIV-1, HIV-2

time form surgery to lab < 6 hours

macroscopic examination for absence of scars, surgical markers or pubic hairs

mean thickness 700 - 900 µm

in line with 3Rs (Reduce, Refine, Replace), replacing animal tests

many different sizes available

in line with OECD 428, EU Regulation 2017/745, Rule 21 for classification of medical devices, EFSA, EMA and FDA guidelines

Skin Absorption/Permeation study services available on skin explants or on 3D organotypic tissue models (skin, oral, vaginal, corneal, bladder, colorectal, nasal, intestinal tissues), please contact info@xenometrix.ch

Other ex vivo skin explants and IVPT services

Ex vivo dermatomed porcine ear skin discs
Ex vivo single bovine nail sheets
Ex vivo dermatomed human skin (abdominal, face)
Ex vivo full thickness human skin (abdominal, face)
Franz diffusion cells, jacketed and unjacketed in many different sizes
Service analytics for in vitro dermal permeation testing, please contact info@xenometrix.ch
Service analytics for Skin irritation (OECD TG439), Skin corrosion (OECD TG431), DPRA, formulation analysis, please contact info@xenometrix.ch

XenoSkin Leaflet

Leaflets

PDF

XenoSkin Leaflet

Service Analytics Genotoxicity

PDF

Service Analytics Genotoxicity

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