XenoSkin H Disk 5 mm - Ex vivo full Thickness Skin Explant for in vitro Dermal Absorption, in vitro Permeation Testing or Penetration Tests, OECD TG428

Art. No.: H-F20D-5

5mm Ø Disks - Frozen Full Thickness Human Abdominal Skin Model/Explant XenoSkin H

Product Description
Documents (2)

XenoSkin H is an ex vivo full thickness human skin explant in a disc format for in vitro dermal permeation tests, skin absorption or penetration safety studies of chemicals, agrochemicals, topically applied pharmaceuticals, cosmetics, biocides, pesticides. The skin explants are also used as in vitro method for the evaluation of the barrier properties of substance based medical devices for cutaneous use according Regulation 2017/745, Rule 21. The discs can be used for the safety assessment according to OECD 428, EFSA, EMA, FDA guidelines and MDR 2017/745.

XenoSkin H discs and porcine mucosas are excellent in vitro models for selecting drug candidates for dermal application, characterization of topical dosage forms, quality and safety assessment, selecting a suitable transdermal vehicle or classification of a substance based medical device. XenoSkin H explants is full in line with 3R and is replacing test animals.

Characteristics for in vitro dermal Permeation Testing

abdominal or face ex vivo skin
average age donor 45 years
quality controlled and approved for absence of HBV, HCV, HIV-1, HIV-2
time form surgery to lab < 6 hours
macroscopic examination for absence of scars, surgical markers or pubic hairs
mean thickness 400 - 600 µmin line with 3Rs (Reduce, Refine, Replace), replacing animal tests
many different sizes available
in line with OECD 428, EU Regulation 2017/745, Rule 21 for classification of medical devices, EFSA, EMA and FDA guidelines
In vitro skin permeation testing services are available on skin explants or on 3D organotypic tissue models (skin, oral, vaginal, corneal, bladder, colorectal, nasal, intestinal tissues), please contact info@xenometrix.ch

Other ex vivo skin explants and IVPT services

Ex vivo dermatomed porcine buccal mucosas
Ex vivo single bovine nail sheets
Ex vivo dermatomed human skin (abdominal, face)
Franz diffusion cells, jacketed and unjacketed in many different sizes
Service analytics for in vitro dermal permeation testing, please contact info@xenometrix.ch
Service analytics for Skin irritation (OECD TG439), Skin corrosion (OECD TG431), DPRA, formulation analysis, please contact info@xenometrix.ch

XenoSkin Leaflet

Leaflets

XenoSkin Leaflet

Service Analytics Genotoxicity

Service Analytics Genotoxicity