In vitro Micronucleus Service with Telomer Centromer Staining
In vitro Micronucleus Service with Telomer Centromer Staining

Art. No.:
SSA-O487TC

Unit
Service Analytics for 1 - X Compounds
Description

Service anayltics with in Vitro Mammalian Cell Micronucleus Test (MNT) according to OECD487 under GLP and non GLP conditions plus Telomere and Centromere Staining for the discrimination of aneugenic and clastogenic test comppunds as well as for increased sensitivity as compared to traditional Micronucleus Assay only. The test is used for in vitro toxicological risk assessment of chemicals, pesticides, cosmetics, plant extracts, water.

Characteristics

  • Telomere and Centromer staining allow the identification of aneugenic (telomere and centromere signals) or clastogenic (only telomere signals) compounds.
  • Improvement of the MNT technique compared to uniform staining
  • The test can be performed in primary human peripheral blood lymphocytes (HPBLs) or in TK6 cells, translocation of the test system to other cell lines is also offered.
  • Increased effects of clastogenic and aneugenic compounds at low doses
  • Reduction of MNT baseline  in circulating lympocytes of heathy donors


 


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